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The Urey-Miller research actually goes against abiogenesis

Contemporary research has failed to provide a viable explanation as to how abiogenesis could have occurred on Earth. The abiogenesis problem is now so serious that most evolutionists today tend to shun the entire field because they are ‘uneasy about stating in public that the origin of life is a mystery, even though behind closed doors they freely admit that they are baffled’ because ‘it opens the door to religious fundamentalists and their god-of-the-gaps pseudo-explanations’ and they worry that a ‘frank admission of ignorance will undermine funding’.

Abiogenesis was once commonly called ‘chemical evolution’, but evolutionists today try to distance evolutionary theory from the origin of life. This is one reason that most evolutionary propagandists now call it ‘abiogenesis’. Chemical evolution is actually part of the ‘General Theory of Evolution’, defined by the evolutionist Kerkut as ‘the theory that all the living forms in the world have arisen from a single source which itself came from an inorganic form’.

Darwin recognized how critical the abiogenesis problem was for his theory. He even conceded that all existing terrestrial life must have descended from some primitive life-form that was originally called into life ‘by the Creator’. But to admit, as Darwin did, the possibility of one or a few creations is to open the door to the possibility of many others! Darwin evidently regretted this concession later and also speculated that life could have originated in some ‘warm little pond’ on the ancient earth.

The ‘warm soup’ theory

Although seriously challenged in recent years, the warm soup hypothesis is still the most widely held abiogenesis theory among Darwinists. Developed most extensively by Russian atheist Alexandr Ivanovich Oparin (1894–1980) in his book, The Origin of Life, a worldwide best seller first published in 1924 (the latest edition was published in 1965). Oparin ‘postulated that life may have evolved solely through random processes’ in what he termed a biochemical ‘soup’ that he believed once existed in the oceans. The theory held that life evolved when organic molecules that originally rained into the primitive oceans from the atmosphere were energized by forces such as lightning, ultraviolet light, meteorites, deep-sea hydrothermal vents, hot springs, volcanoes, earthquakes, or electric discharges from the sun. If only the correct mix of chemicals and energy were present, life would be produced spontaneously. Almost a half century of research and millions of dollars have been expended to prove this idea—so far with few positive results and much negative evidence.

What sequence?

Oparin concluded that cells evolved first, then enzymes and, last, genes. Today, we recognize that genes require enzymes in order to function, but genes are necessary to produce enzymes. Neither genes nor cells can function without many complex structures such as ribosomes, polymerase, helicase, gyrase, single-strand–binding protein and scores of other proteins. Dyson concluded that Oparin’s theory was ‘generally accepted by biologists for half a century’ but that it ‘was popular not because there was any evidence to support it but rather because it seemed to be the only alternative to biblical creationism’.

The Miller–Urey research

Haldane, Bernal, Calvin and Urey all published research in an attempt to support this model—each with little, if any, success. Then, in 1953 came what some then felt was a critical breakthrough by Harold Urey (1893–1981) of the University of Chicago and his 23-year-old graduate student, Stanley Miller (1930–). Urey came to believe that the conclusion reached by ‘many’ origin-of-life researchers that the early atmosphere was oxidizing must have been wrong; he argued instead that it was the opposite, namely a reducing atmosphere with large amounts of methane.

Their ‘breakthrough’ resulted in front-page stories across the world that usually made the sensational claim that they had ‘accomplished the first step toward creating life in a test tube’. Carl Sagan concluded, ‘The Miller–Urey experiment is now recognized as the single most significant step in convincing many scientists that life is likely to be abundant in the cosmos.’ The experiment even marked the beginning of a new scientific field called ‘prebiotic’ chemistry. It is now the most commonly cited evidence (and often the only evidence cited) for abiogenesis in science textbooks.

The Miller–Urey experiments involved filling a sealed glass apparatus with the gases that Oparin had speculated were necessary to form life—namely methane, ammonia and hydrogen (to mimic the conditions that they thought were in the early atmosphere) and water vapour (to simulate the ocean). Next, while a heating coil kept the water boiling, they struck the gases in the flask with a high-voltage (60,000 volts) tungsten spark-discharge device to simulate lightning. Below this was a water-cooled condenser that cooled and condensed the mixture, allowing it to fall into a water trap below.

Within a few days, the water and gas mix produced a pink stain on the sides of the flask trap. As the experiment progressed and the chemical products accumulated, the stain turned deep red, then turbid. After a week, the researchers analyzed the substances in the U-shaped water trap used to collect the reaction products. The primary substances in the gaseous phase were carbon monoxide (CO) and nitrogen (N2). The dominant solid material was an insoluble toxic carcinogenic mixture called ‘tar’ or ‘resin’, a common product in organic reactions, including burning tobacco. No amino acids were detected during this first attempt, so Miller modified the experiment and tried again.

In time, trace amounts of several of the simplest biologically useful amino acids were formed—mostly glycine and alanine. The yield of glycine was a mere 1.05%, of alanine only 0.75% and the next most common amino acid produced amounted to only 0.026% of the total—so small as to be largely insignificant. In Miller’s words, ‘The total yield was small for the energy expended.’ The side group for glycine is a lone hydrogen and for alanine, a simple methyl (–CH3) group.

Oxygen: enemy of chemical evolution

The researchers used an oxygen-free environment mainly because the earth’s putative primitive atmosphere was then ‘widely believed not to have contained in its early stage significant amounts of oxygen’. They believed this because ‘laboratory experiments show that chemical evolution, as accounted for by present models, would be largely inhibited by oxygen’. Here is one of many examples of where their a prioribelief in the ‘fact’ of chemical evolution is used as ‘proof’ of one of the premises, an anoxic atmosphere. Of course, estimates of the level of O2 in the earth’s early atmosphere rely heavily on speculation. The fact is, ‘We still don’t know how an oxygen-rich atmosphere arose.’

It was believed that the results were significant because some of the organic compounds produced were the building blocks of much more complex life units called proteins—the basic structure of all life. Although widely heralded by the press as ‘proving’ that life could have originated on the early earth under natural conditions (i.e. without intelligence), we now realize the experiment actually provided compelling evidence for exactly the opposite conclusion. For example, without all 20 amino acids as a set, most known protein types cannot be produced, and this critical step in abiogenesis could never have occurred.

In addition, equal quantities of both right- and left-handed organic molecules (called a racemic mixture) were consistently produced by the Miller–Urey procedure. In life, nearly all amino acids that can be used in proteins must be left-handed, and almost all carbohydrates and polymers must be right-handed. The opposite types are not only useless but can also be toxic (even lethal) to life.

Was there a methane–ammonia atmosphere?

According to many researchers today, an even more serious problem is the fact that the atmosphere of the early earth was very different from what Miller assumed. ‘Research has since drawn Miller’s hypothetical atmosphere into question, causing many scientists to doubt the relevance of his findings.’ The problem was stated as follows:

‘… the accepted picture of the earth’s early atmosphere has changed: It was probably O2-rich with some nitrogen, a less reactive mixture than Miller’s, or it might have been composed largely of carbon dioxide, which would greatly deter the development of organic compounds.’

A major source of gases was believed to be volcanoes, and since modern-day volcanoes emit CO, CO2, N2 and water vapour, it was considered likely that these gases were very abundant in the early atmosphere. In contrast, it is now believed that H2, CH4 and NH3 probably were not major components of the early atmosphere.

Although the composition of the atmosphere of the early earth is now believed to have consisted of large amounts of carbon dioxide, this conclusion still involves much speculation. Most researchers also now believe that some O2 was present on the early earth because it contained much water vapour, and photodissociation of water in the upper layers of the atmosphere produces oxygen. Another reason is that large amounts of oxidized materials exist in the Precambrian geological strata.

Yet another reason to conclude free oxygen existed on the early earth is that it is widely believed that photosynthetic organisms existed very soon after the earth had formed, something that is difficult for chemical evolutionary theories to explain. A 2004 paper argues from uranium geochemistry that there were oxidizing conditions, thus photosynthesis, at 3.7 Ga.37 But according to uniformitarian dating, the earth was being bombarded by meteorites up to 3.8 Ga. So even granting evolutionary presuppositions, this latest research shows that life existed almost as soon as the earth was able to support it, not ‘billions and billions of years’ later. Even if the oxygen were produced by photodissociation of water vapour rather than photosynthesis, this would still be devastating for Miller-type proposals.

Early hopes not realized

Modern replications of the Miller–Urey experiment using a wide variety of recipes, including low levels of O2, yield even lower amounts of organic compound than the original experiment. To solve this problem, some researchers have speculated that small, isolated pools of water achieved the required level of concentration. The same problem remains: No feasible method exists to account for this source. Some even speculate that ‘submerged volcanoes and deep-sea vents—gaps in the earth’s crust where hot water and minerals gush into deep oceans—may have provided the initial chemical resources’.

To duplicate what might have happened in a primordial soup billions of years ago, scientists would need to mix the chemicals currently believed to be commonly found on the early earth, expose them to likely energy sources (usually speculated to be heat or radiation), and see what happens. No-one has performed this experiment, because we now know that it is impossible to obtain relevant biochemical compounds by this means. The Miller–Urey experiment held great hopes for the materialists, which have now given way to pessimism:

‘Soon after the Miller–Urey experiment, many scientists entertained the belief that the main obstacles in the problem of the origin of life would be overcome within the foreseeable future. But as the search in this young scientific field went on and diversified, it became more and more evident that the problem of the origin of life is far from trivial. Various fundamental problems facing workers in this search gradually emerged, and new questions came into focus … . Despite intensive research, most of these problems have remained unsolved.

‘Indeed, during the long history of the search into the origin of life, controversy is probably the most characteristic attribute of this interdisciplinary field. There is hardly a model or scenario or fashion in this discipline that is not controversial.’

Some of these major problems will now be reviewed.

Functional proteins can exist only in very narrow conditions

To produce even non-functional amino acids and proteins, researchers must highly control the experiment in various ways because the very conditions hypothesized to create amino acids also rapidly destroy proteins. Examples include thermal denaturing of proteins by breaking apart their hydrogen bonds and disrupting the hydrophobic attraction between non-polar side groups. Very few proteins remain biologically active above 50ºC, or below about 30ºC, and most require very narrow conditions. As any molecular biologist knows from daily lab work, the pH also must be strictly regulated. Too much acid or base adversely affects the hydrogen bonding between polar R groups and also disrupts the ionic bonds formed by the salt bridges in protein.


Miller had to deal with the fact that the common cross-reactions of biochemical reaction products cause destruction or interfere with amino acid production. All compounds that interfere with bonding must be isolated or they will destroy the proteins.

This is no small problem. Many organic compounds, such as ethanol and isopropyl alcohol, function as disinfectants by forming their own hydrogen bonds with a protein and, as a result, disrupt the proteins’ hydrophobic interactions. Alcohol swabs are used to clean wounds or to prepare skin for injections because the alcohol passes through cell walls and coagulates the proteins inside bacteria and other cells. Also, heavy metal ions such as Ag+, Pb2+ and Hg2+ must be isolated from proteins because they disrupt the protein’s disulfide bonds, causing the protein to denature. As an example, a dilute (1%) AgNO3 solution is placed in the eyes of newborn babies to destroy the bacteria that cause gonorrhea. Many heavy metal ions are very toxic if ingested because they severely disrupt protein structure, especially enzymes.

Another problem is that many of the other compounds necessary for life, such as sugar, also react strongly with amino acids and affect amino acid synthesis. For example, Miller and others had to use a sugar-free environment in their experiments. Miller stopped his experiment after just a few days, but if it had been allowed to go on, would the compounds he produced be destroyed or would they produce more complex amino acids?

The Miller–Urey experiments produced many other compounds aside from amino acids, as toxic compounds such as cyanides, carbon monoxide, and others.

Undirected energy is disruptive

A critical question, ‘How much energy was necessary?’ has been much debated. However, all forms of energy can disrupt protein, including all of those forms postulated to be important in abiogenesis, such as UV and lightning.

Many speculate that ultraviolet light was the source used to create life, but UV is highly toxic to life, and is, in fact, often used to destroy life (thus UV lights are used in hospitals to kill micro-organisms). The intensity of the destructive long wavelengths exceeds that of the constructive short ones, and the quantum efficiency of destruction is much higher than that for construction as well. This means that destruction of amino acids is four to five orders of magnitude higher than construction.

In Miller’s UV experiments, he used a select wavelength to produce amino acids and screened out other wavelengths because they destroy amino acids, which are very delicate and readily break down under natural sunlight.

The Miller–Urey experiment also had strategically designed traps to remove the products from the radiation before they could be destroyed.

Miller’s research has, for the reasons discussed above, helped us to better understand why life could not have emerged naturally. In a summary of the famous Miller–Urey origin-of-life experiment, Horgan concluded that Miller’s results at first seemed to

‘… provide stunning evidence that life could arise from what the British chemist J.B.S. Haldane had called the “primordial soup.” Pundits speculated that scientists, like Mary Shelley’s Dr. Frankenstein, would shortly conjure up living organisms in their laboratories and thereby demonstrate in detail how genesis unfolded. It hasn’t worked out that way. In fact, almost 40 years after his original experiment, Miller told me that solving the riddle of the origin of life had turned out to be more difficult than he or anyone else had envisioned.’

Creating life in a test tube also turned out to be far more difficult than Miller expected. Scientists now know that the complexity of life is far greater than Miller (or anyone else) imagined in 1953, prior to the DNA revolution.

Life is far more complex than Miller believed

About the same time as Darwin, T.H. Huxley proposed a simple, two-step method of chemical recombination that he thought could explain the origin of the first living cell. Both Haeckel and Huxley thought that just as salt could be produced spontaneously by mixing powered sodium metal and heated chlorine gas, a living cell could be produced merely by mixing the few chemicals they believed were required. Haeckel taught that the physical basis of life is a substance he called ‘plasm’ of different types such as ‘colourless’ and ‘also red, orange, and other kinds of protoplasm’ that were comparable in complexity and texture to a pot of glue or cold jelly.

Haeckel also believed that the first single cell owed its ‘existence to spontaneous creation’ from inorganic compounds, primarily ‘carbon, hydrogen, oxygen, and nitrogen’. As late as 1928, the cell was still thought to be relatively simple, and few scientists then questioned the belief that life commonly developed from relatively simple to relatively complex forms. They also thought evolution was ‘the formation of new structures and functions by combinations and transformations of the relatively simple structures and functions of the germ cells.’

We now also realize, after a century of research, that the eukaryote protozoa, believed in Darwin’s day to be as simple as a bowl of gelatin, are actually enormously complex. Molecular biology has demonstrated that the basic design of the cell is

‘… essentially the same in all living systems on earth from bacteria to mammals. … In terms of their basic biochemical design … no living system can be thought of as being primitive or ancestral with respect to any other system, nor is there the slightest empirical hint of an evolutionary sequence among all the incredibly diverse cells on earth.’

The polymerization problem

The Miller–Urey experiment left many critical questions unanswered. Chemicals do not produce life; only complex structures such as DNA and enzymes produce life. Also, even if the source of the amino acids and the many other compounds needed could be explained, how these many diverse elements became aggregated in the same area and then properly assembled themselves must still be dealt with. This problem is a major stumbling block to all abiogenesis theories because

‘… no one has ever satisfactorily explained how the widely distributed ingredients linked up into proteins. Presumed conditions of primordial earth would have driven the amino acids toward lonely isolation. That’s one of the strongest reasons that Wächtershäuser, Morowitz, and other hydrothermal vent theorists want to move the kitchen [that cooked life] to the ocean floor. If the process starts down deep at discrete vents, they say, it can build amino acids—and link them up—right there.’

The amino acid assembly problem is complicated by the fact that amino acids are able to bond in many locations by many kinds of chemical bonds. To form polypeptide chains requires restricting the links to only peptide bonds, and only in the correct locations. All other bonds must be prevented from being formed, no easy task. In living cells, a complex control system involving enzymes exists to ensure that inappropriate bonds do not normally occur.

Information content

Another major reason the Miller–Urey experiments failed to support abiogenesis was that, although amino acids are the building blocks of life, a critical key to life is the information code stored in DNA (or, as in the case of retroviruses, RNA), depending on the sequence of nucleotides. This in turn provides the instructions for the amino acid sequences for the proteins, the machinery of life. Michael Polanyi (1891–1976), former chairman of physical chemistry at the University of Manchester (UK) who turned to philosophy, affirmed a very important point—the information was something above the chemical properties of the building blocks:

‘As the arrangement of a printed page is extraneous to the chemistry of the printed page, so is the base sequence in a DNA molecule extraneous to the chemical forces at work in the DNA molecule. It is this physical indeterminacy of the sequence that produces the improbability of any particular sequence and thereby enables it to have a meaning—a meaning that has a mathematically determinate information content.’

Another huge problem is that information is useless unless it can be read. But the decoding machinery is itself encoded on the DNA. The leading philosopher of science, Karl Popper (1902–1994), expressed the huge problem:

‘What makes the origin of life and of the genetic code a disturbing riddle is this: the genetic code is without any biological function unless it is translated; that is, unless it leads to the synthesis of the proteins whose structure is laid down by the code. But … the machinery by which the cell (at least the non-primitive cell, which is the only one we know) translates the code consists of at least fifty macromolecular components which are themselves coded in the DNA. Thus the code can not be translated except by using certain products of its translation. This constitutes a baffling circle; a really vicious circle, it seems, for any attempt to form a model or theory of the genesis of the genetic code.

‘Thus we may be faced with the possibility that the origin of life (like the origin of physics) becomes an impenetrable barrier to science, and a residue to all attempts to reduce biology to chemistry and physics.’

The chirality problem

What Sarfati calls a ‘major hurdle’ is the origin of homochirality, the fact that all amino acid biomolecules with rare exceptions (such as some used in bacterial cell walls) are all left-handed; and with rare exceptions, all sugars, including those in nucleic acids, are right-handed. Those produced in a laboratory are a half left-handed and half right-handed mixture called a racemate. Even in the laboratory, chemists use pre-existing homochirality from a biological source in order to synthesize homochiral compounds. Chiral molecules are dissymmetric—they exist as mirror images of each other, just as the right hand is a mirror image of the left hand (the word chiral comes from the Greek word for ‘hand’). The problem is left-handed sugars and right-handed amino acids can be toxic and prevent abiogenesis. Furthermore, most all enzymes are designed to work only with right-handed sugars and left-handed amino acids. All attempts to solve the chirality problem, including magnetochiral dichroism, have failed.


It is now recognized that the Miller–Urey line of research is simply a ‘revival of the antique notion of spontaneous generation’ because it

‘… suggests that given the primordial soup, with the right combination of amino acids and nucleic acids, and perchance a lightning bolt or two, life might in fact have begun “spontaneously”. The major difference is that according to what biologists customarily called spontaneous generation, life supposedly began this way all of the time. According to the “soup” suggestion, by contrast, it began this way only once in the immeasurably distant past.’

We must conclude, as Ridley did, that the early forms of life, and how natural selection could shape them, are ‘so obscure at the primordial stage that we can only guess why complexity might have increased’.

From: Creation Ministries


2 responses to “The Urey-Miller research actually goes against abiogenesis

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